Computational models and simulations are an important tool for the analysis and optimisation of various pharmaceutical unit operations, process equipment, drug delivery devices and quality control equipment.   

 Analysis is included in most manufacturer’s process as an integral part of the Quality by Design (QbD) procedure for the design of new systems. It can help shorten product development cycles, optimise processes to improve repeatability, efficiency, and productivity, identify problems as they arise during operation and reduce costs.  

Historically manufacturing companies have relied on 1D chemical models, experience and the regulator’s recommendations for the dimensioning and design of both the process and the required equipment. However, the current market demands the pharma-manufacturing leaders to manage smaller batches, shorter runs, greater complexity, more volatile demand, and ever-increasing quality expectations.  Computational simulation techniques such as Finite Element Analysis (FEA) and Computational Fluid Dynamics (CFD) are gaining more relevance as part of the design process for most pharma companies. Trescon Engineering have developed a set of models and procedures for the accurate analysis of most unit operations included in current drug production systems. Whether for a new machine design, the refurbishment or retrofitting of a used one or for a forensics analysis for a failing process, Trescon will help your design team find the solution. 

PHARMACEUTICALS EQUIPMENT

>> Heating and cooling equipment optimisation: Heat pumps, chillers and H.E.

>>FEA Stress and fatigue calculations for high pressure equipment.

 

>> Clean room HVAC modelling: CFD analysis

>>   Bioreactors performance assessment: Cell culture growth modelling

>>   Fluid dynamics modelling for centrifuges and separators

>>   Fluid bed processors analysis: Nozzle and chamber CFD optimization

>>   Reactors analysis: Chemical kinetics models and thermal analysis 

MEDICAL EQUIPMENT

>>   Thermal management simulations for medical equipment

>>   Stress and fatigue assessment for cyclically loaded equipment

>>   Electromagnetic simulation for testing and scanning equipment

>>   Multi-component equipment stress analysis

DRUG DELIVERY

>>  Mass production product optimisation studies: Material use, moulding and performance assessment

>>  Single and multiple compound syringe: pre-mixing and delivery CFD models

>>  Respirators optimisation: Spray flow modelling>>  Metering